The economic impact of the global pandemic on developing countries has been diverse and profound. These countries, belonging to the low and middle economic categories, experienced a stronger impact compared to developed countries. Some of the main factors influencing the economic conditions of developing countries during the pandemic include a decline in foreign investment, unemployment, and disruption to supply chains. First, the decline in foreign direct investment (FDI) is a significant problem. Global investors are holding back their investments due to the uncertainty brought about by the pandemic. In countries such as Indonesia, Brazil and India, key sectors such as manufacturing and tourism have experienced drastic declines. This leads to loss of job opportunities and deepens the local economic crisis. Second, unemployment has increased drastically. Many businesses were forced to close operations, and employees were fired or laid off. The informal sector, which dominates developing countries’ economies, is particularly vulnerable to these shocks. According to a report from the International Labor Organization (ILO), millions of workers in developing countries are losing their sources of income, which exacerbates poverty and social injustice. Third, disruptions in global supply chains worsen economic conditions. Many developing countries depend on exports of commodities and manufactured products. When global purchasing countries experience a decline in demand, developing countries’ exports are affected. Port closures and travel restrictions also disrupt the distribution of goods and increase logistics costs. Furthermore, the health sector which was hit hard affected the economy. Developing countries often have already weak health systems, making the burden of the pandemic even heavier. The budget that should be allocated for infrastructure development, education and health must be diverted to handling COVID-19. This will have a long-term impact on economic growth. On the other hand, the pandemic also provides opportunities for innovation. Many developing countries are starting to adapt to digital technology. For example, the small and medium enterprise (SME) sector is developing new business models through online platforms. These opportunities could influence the way businesses operate going forward, even though the road to economic recovery remains long and full of challenges. Governments in developing countries have implemented various policy measures to overcome this crisis. Steps in the form of fiscal stimulus, social assistance and strengthening health infrastructure are the main focus. However, the effectiveness of this policy is often hampered by budget constraints and inefficient bureaucracy. Finally, the role of the international community is very important in supporting the economic recovery of developing countries. Support from international financial institutions, such as the World Bank and IMF, in the form of loans and technical assistance will help these countries deal with the long-term impacts. Handling the economic crisis caused by the pandemic requires global cooperation so that developing countries are not left behind.